MORPHOLOGICAL CHARACTERISTICS OF SCAR TISSUE AFTER CESAREAN SECTION WITH UNFAVORABLE OUTCOMES

UDC 618.5-089.888.61-091

Authors

  • Olga Yu. Pachkovskaya River Medical Center, Barnaul, Russia Email: pipulj@mail.ru
  • Maria G. Nikolaeva Altai State Medical University, Barnaul, Russia; Altai branch of National Medical Research Center of Hematology, Barnaul, Russia Email: nikolmg@yandex.ru
  • Marina B. Igitova Altai State Medical University, Barnaul, Russia Email: igitova-2011@mail.ru

DOI:

https://doi.org/10.31684/25418475-2023-3-94

Keywords:

uterine scar, pregnancy, perinatal lesions of the central nervous system, morphological examination, microcirculation dysfunction

Abstract

Objective: to evaluate changes in the morphology of scar tissue tissues after cesarean section with unfavorable perinatal outcomes in the consecutive pregnancy. Materials and methods. A morphological study of a resected scar on the uterus after a previous cesarean section was performed. The main group (n=28) included samples of scar tissues of patients in case of unfavorable perinatal outcomes;  the comparison group (n=32) included biological samples of 32 pregnant women at birth of healthy newborns with an Apgar score of 7 or more points and no signs of physiological immaturity and fetal growth retardation. Results. In case of unfavorable perinatal outcomes significantly more often uneven and/or weak blood filling of the microvasculature was determined (p=0,0483 and p=0,0492 respectively) in the area of scar tissue regarding to the group of women at the birth of healthy children. In contrast, the comparison group is characterized by a significantly larger number of sections with neoangiogenesis (p=0,0452). The most significant difference in the histological pattern of the scar tissue of the comparison groups was the presence of moderate diffuse intermuscular stroma edema: in 85,7% of the samples of the main group and in 56,3% of the comparison group (p=0,0173). Conclusion. It can be assumed that the formation of placental dysfunction with an outcome of unfavorable perinatal outcomes in patients with a scar on the uterus after cesarean section is preceded by a violation of the formation of an adequate uterine structure in the scar area due to local microcirculation dysfunction.

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Author information

Olga Yu. Pachkovskaya,
River Medical Center, Barnaul, Russia

Obstetrician-Gynecologist, Medical Center "River", Barnaul; Postgraduate student of the Department of Obstetrics and Gynecology with Advanced Training Course, Altai State Medical University, Barnaul. 656056, Barnaul, Bavarina square, 1, Н1.
E-mail: pipulj@mail.ru

Maria G. Nikolaeva,
Altai State Medical University, Barnaul, Russia; Altai branch of National Medical Research Center of Hematology, Barnaul, Russia

Dr. Sci. (Med.), Professor, Department of Obstetrics and Gynecology with Advanced Training Course, Altai State Medical University, Barnaul; Senior Researcher, Altai Branch of the National Medical Research Center of Hematology, Ministry of Health of the Russian Federation, Barnaul. E-mail: nikolmg@yandex.ru

Marina B. Igitova,
Altai State Medical University, Barnaul, Russia

Dr. Sci. (Med.), Professor, Professor of the Department of Obstetrics and Gynecology with Advanced Training Course, Altai State Medical University, Barnaul. E-mail: igitova-2011@mail.ru

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    Published

    2023-09-15

    How to Cite

    Pachkovskaya O. Y., Nikolaeva M. G., Igitova M. B. MORPHOLOGICAL CHARACTERISTICS OF SCAR TISSUE AFTER CESAREAN SECTION WITH UNFAVORABLE OUTCOMES: UDC 618.5-089.888.61-091 // Bulletin of Medical Science, 2023. Vol. 31, № 3. P. 94–99 DOI: 10.31684/25418475-2023-3-94. URL: https://newbmn.asmu.ru/bmn/article/view/611.

    Issue

    Vol. 31 No. 3 (2023): Bulletin of Medical Science

    Section

    ORIGINAL PAPERS

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    Copyright (c) 2023 Ольга Юрьевна Пачковская, Мария Геннадьевна Николаева, Марина Борисовна Игитова

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    This work is licensed under a Creative Commons Attribution 4.0 International License.

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