RESULTS OF HEALING BURN WOUNDS USING WOUND DRESSINGS BASED ON BACTERIAL CELLULOSE IN THE EXPERIMENT

UDC 616-001.4-001.17:615.468

Authors

  • Andrey N. Zharikov Altai State Medical University, Barnaul, Russia https://orcid.org/0000-0003-4292-4781 Email: zhar67@mail.ru
  • Alexander R. Aliev Altai State Medical University, Barnaul, Russia https://orcid.org/0000-0002-4506-3799 Email: alievar10@mail.ru
  • Olga V. Orlova Altai State Medical University, Barnaul, Russia Email: olgavin209@gmail.com
  • Lyubov G. Dvornikova Altai State Medical University, Barnaul, Russia Email: lioubov.dv@mail.ru
  • Olesya N. Mazko Altai State Medical University, Barnaul, Russia https://orcid.org/0000-0001-7299-4516 Email: olesia.mazko@yandex.ru
  • Olesya G. Makarova Altai State Medical University, Barnaul, Russia Email: olesia552@mail.ru
  • Vasily V. Prokopiev Altai State Medical University, Barnaul, Russia Email: mikrob2b@mail.ru
  • Natalya M. Semenikhina Altai State Medical University, Barnaul, Russia Email: semenihina85@list.ru

DOI:

https://doi.org/10.31684/25418475-2023-3-19

Keywords:

deep skin burns, experimental studies, wound dressings, bacterial cellulose, wound epithelialization, microbial contamination

Abstract

Purpose of the study: in experimental studies to evaluate the effectiveness of healing and changes in the microbial spectrum of deep burn wounds during their treatment using wound dressings based on bacterial cellulose. Materials and methods. The object of the experimental studies was 60 Wistar rats, which formed a deep skin burn. All animals were divided into 3 groups, of which in group 1 (n=20) burn wounds were treated with pure wet bacterial cellulose (BC) wound dressings, in group 2 (n=20) BC was used with exposure to a 1% chlorhexidine and in group 3 (n=20) traditional treatment was performed with Levomekol ointment. On days 5, 10, 15, 20, 28 in the groups, the area of the wound surfaces, the dynamics of their decrease, and the microbial spectrum were studied. Results and conclusions. We registered that wound dressings based on wet bacterial cellulose, applied in pure form and with exposure to an antiseptic (1% chlorhexidine solution) for 28 days, increase the healing rate of burn wounds by an average of 18% compared to the traditional treatment group. The formed scab over the wound, when BC dries, provides the wound surface with a mechanical protective barrier that prevents injury to emerging dermal cells, microbial contamination and thereby increases the rate of epithelialization in a closed environment.

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Author information

Andrey N. Zharikov,
Altai State Medical University, Barnaul, Russia

Dr. Sci. (Med.), Associate Professor, Head of the Department of Hospital Surgery, Altai State Medical University, Barnaul. 656024, Altai Krai, Barnaul, Lyapidevskogo Str. 1.
E-mail: zhar67@mail.ru
https://orcid.org/0000-0003-4292-4781

Alexander R. Aliev,
Altai State Medical University, Barnaul, Russia

Cand. Sci. (Med.), Associate Professor, Department of Hospital Surgery, Altai State Medical University, Barnaul.
E-mail: alievar10@mail.ru
https://orcid.org/0000-0002-4506-3799

Olga V. Orlova,
Altai State Medical University, Barnaul, Russia

Senior Lecturer, Department of Anatomy, Altai State Medical University, Barnaul. E-mail: olgavin209@gmail.com

Lyubov G. Dvornikova,
Altai State Medical University, Barnaul, Russia

Cand. Sci. (Pharm.), Associate Professor, Department of Pharmacy, Altai State Medical University, Barnaul.
E-mail: lioubov.dv@mail.ru

Olesya N. Mazko,
Altai State Medical University, Barnaul, Russia

Cand. Sci. (Biol.), Associate Professor of the Department of Pharmacology named after Professor V.M. Brukhanov, Altai State Medical University, Barnaul.
E-mail: olesia.mazko@yandex.ru
https://orcid.org/0000-0001-7299-4516

Olesya G. Makarova,
Altai State Medical University, Barnaul, Russia

Cand. Sci. (Pharm.), Associate Professor, Department of Pharmacy, Altai State Medical University, Barnaul.
E-mail: olesia552@mail.ru

Vasily V. Prokopiev,
Altai State Medical University, Barnaul, Russia

Cand. Sci. (Biol.), Associate Professor, Department of Epidemiology, Microbiology and Virology, Altai State Medical University, Barnaul.
E-mail: mikrob2b@mail.ru

Natalya M. Semenikhina,
Altai State Medical University, Barnaul, Russia

Cand. Sci. (Vet.), Associate Professor, Department of Anatomy, Altai State Medical University, Barnaul.
E-mail: semenihina85@list.ru

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    2023-09-15

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    Zharikov A. N., Aliev A. R., Orlova O. V., Dvornikova L. G., Mazko O. N., Makarova O. G., Prokopiev V. V., Semenikhina N. M. . RESULTS OF HEALING BURN WOUNDS USING WOUND DRESSINGS BASED ON BACTERIAL CELLULOSE IN THE EXPERIMENT: UDC 616-001.4-001.17:615.468 // Bulletin of Medical Science, 2023. Vol. 31, № 3. P. 19–29 DOI: 10.31684/25418475-2023-3-19. URL: https://newbmn.asmu.ru/bmn/article/view/602.

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    Vol. 31 No. 3 (2023): Bulletin of Medical Science

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    ORIGINAL PAPERS

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    Copyright (c) 2023 Андрей Николаевич Жариков, Александр Руштиевич Алиев, Ольга Владимировна Орлова, Любовь Габдулбариевна Дворникова, Олеся Николаевна Мазко, Олеся Геннадьевна Макарова, Василий Валерьевич Прокопьев, Наталья Михайловна Семенихина

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