VEGETATIVE DYSFUNCTION IN CHRONIC OPISTHORCHIASIS

УДК 616.995.122:616.839

Authors

DOI:

https://doi.org/10.31684/25418475-2023-4-94

Keywords:

chronic opisthorchiasis, Opisthorchis felineus, autonomic nervous system, parasympathetic nervous system, sympathetic nervous system, heart rate variability, cardiointervalography

Abstract

Introduction. Altai Krai is one of the most significant natural foci of opisthorchiasis not only in Western Siberia, but also on the territory of the Russian Federation as a whole, where the incidence of opisthorchiasis ranges from 44 to 34 per 100,000 people. The primary habitat of opisthorchiasis is the hepatobiliary system; the polymorphism of long-term invasion polymorphism is characterized by a violation of the functions of many organs and systems: liver, immune and cardiovascular systems, digestive organs, etc. The control center responsible for these vital functions of the body is the autonomic nervous system, which regulates them in the body. Analysis of heart rate variability can give an idea of sympathetic-parasympathetic vegetative balance. The purpose of the study. A comprehensive study of the state of autonomic regulation by analyzing heart rate variability in patients with chronic opisthorchiasis. Materials and methods. During the course of the study, 31 patients with chronic opisthorchiasis (CO) were observed, a comparison was made with 30 healthy individuals of similar age and gender. When studying the function of the autonomic nervous system, the method of mathematical analysis of the heart rate according to R.M. Baevsky was used with the help of the original program "CORVEG". The level of critical significance of the null statistical hypothesis was assumed to be 0.05. Results and Discussion. In the study of the nature of vegetative changes, methods of frequency and spectral analysis of heart rate were used. Changes in heart rate regulation indicators were statistically significantly (p<0.05) indicated an increase in sympathetic regulation at rest and orthostasis in patients with SC, their autonomic homeostasis was shifted toward the sympathetic nervous system both at rest and under load, and in some patients (31%) dysregulation of the central type was detected. Conclusions. Dysregulation of autonomic nervous system in patients with chronic opisthorchiasis was revealed at all levels of its regulation and was characterized by increased sympathetic tone and a decrease in parasympathetic and humoral regulation, as well as vasoreflective and baroreflective mechanisms.

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Ekaterina Yu. Plotnikova,
Kemerovo State Medical University, Kemerovo, Russia

Dr. Sci. (Med.), Professor of the Department of Primary Health Care Physician Training, Head of Clinical Gastroenterology Course, Kemerovo State Medical University, Kemerovo.
E-mail: eka-pl@rambler.ru
https://orcid.org/0000-0002-6150-1808

Nina V. Karbysheva,
Altai State Medical University, Barnaul, Russia

Dr. Sci. (Med.), Professor, Head of the Department of Infectious Diseases with Advanced Training Course, Altai State Medical University, Barnaul.
656038, Altai Krai, Barnaul, Lenina Ave. 40.
E-mail: nvk80@rambler.ru
https://orcid.org/0000-0001-8320-3468

Marina A. Nikonorova,
Altai State Medical University, Barnaul, Russia

Dr. Sci. (Med.), Associate Professor, Professor of the Department of Infectious Diseases with Advanced Training Course, Altai State Medical University, Barnaul.
E-mail: ma.nikulina@mail.ru
https://orcid.org/0000-0001-6621-9310

Olga V. Beskhlebova,
Altai State Medical University, Barnaul, Russia

Cand. Sci. (Med.), Associate Professor, Department of Infectious Diseases with Advanced Training Course, Altai State Medical University, Barnaul.
E-mail: olg.deriglazova@yandex.ru
https://orcid.org/0000-0003-4561-1019

Maria E. Ivanova,
Altai State Medical University, Barnaul, Russia

Assistant of Infectious Diseases Department, Altai State Medical University, Barnaul.
E-mail: ivanova.akcomd@yandex.ru

Irina V. Osipova,
Altai State Medical University, Barnaul, Russia

Dr. Sci. (Med.), Professor, Head of the Department of Faculty Therapy and Occupational Diseases, Altai State Medical University, Barnaul.
E-mail: k-fakter@asmu.ru
https://orcid.org/0000-0001-9998-5409

Maksim A. Sinkov,
Research Institute of Complex Problems of Cardiovascular Diseases, Kemerovo, Russia

Cand. Sci. (Med.), Cardiovascular Surgeon, Research Institute of Complex Problems of Cardiovascular Diseases, Kemerovo.
E-mail: eka-pl@rambler.ru
https://orcid.org/0000-0002-2494-8694

Irina N. Kiushkina,
Altai State Medical University, Barnaul, Russia

Cand. Sci. (Med.), Associate Professor, Department of Infectious Diseases with Advanced Training Course, Altai State Medical University, Barnaul.
E-mail: i.kiushkina@mail.ru.

References

  • On the state of sanitary and epidemiological well-being of the population in the Russian Federation in 2022: State Report. Moscow: Federal Service for Supervision of Consumer Rights Protection and Human Welfare, 2023. 368 p.
  • Metz C.N., Pavlov V.A. Vagus nerve cholinergic circuitry to the liver and the gastrointestinal tract in the neuroimmune communicatome. Am J Physiol Gastrointest Liver Physiol. 2018; 315: 651-8. https://doi.org/10.1152/ajpgi.00195.2018
  • Targher G., Day C.P., Bonora E. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med. 2010; 363: 1341-1350. https://doi.org/10.1056/NEJMra0912063
  • Houghton D., Zalewski P., Hallsworth K., Cassidy S., Thoma C., Avery L, Slomko J., Hardy T., Burt A. D., Tiniakos D., Hollingsworth K. G., Taylor R., Day C. P., Masson S., Pherson S.M, Anstee Q. M., Newton J. L., Trenell M.I. The degree of hepatic steatosis associates with impaired cardiac and autonomic function. Journal of Hepatology. 2019; 70(6): 1203-1213. https://doi.org/10.1016/j.jhep.2019.01.035
  • Cai Z., Cheng H., Xing Y., Chen F., Zhang Y., Cui C. Autonomic nervous activity analysis based on visibility graph complex networks and skin sympathetic nerve activity. Front. Physiol. 2022; 13: 1001415. https://doi.org/10.3389/fphys.2022.1001415.
  • Task Force of ESC and NASPE. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation. 1996; 93: 1043-1065.
  • Thomas B.L., Claassen N., Becker P., Viljoen M. Validity of Commonly Used Heart Rate Variability Markers of Autonomic Nervous System Function. Neuropsychobiology. 2019; 78: 14-26. https://doi.org/10.1159/000495519.
  • Skorić K.M., Adamec I., Cifrek M., Habek M. Analysis of Autonomic Nervous System Biosignals. In: Badnjevic A, Gurbeta Pokvić L. (eds) CMBEBIH 2021. IFMBE Proceedings. 2021; 84. Springer, Cham. https://doi.org/10.1007/978-3-030-73909-6_3.
  • Plotnikova E.Y., Baranova E.N. Problems of treatment of opisthorchiasis invasion. RMZ. Medical Review. 2018; 3: 53-56. https://www.rmj.ru/articles/gastroenterologiya/Problemy_lecheniyaopistorhoznoy_invazii/.
  • Ivanova M.E. et al. Diagnosis of cardiovascular disorders in opisthorchiasis invasion in residents of Altai Krai. Proceedings of the international congress "Infectious diseases, microbiology and immunology". 2017; 15(3): 65-66.
  • Khoroshilova I.A. et al. Diagnostic approaches in opisthorchiasis infestation. Journal of Infectology. 2023; 15: 140.
  • Baevsky R.M., Kirillov O.V., Kletskin S.Z. Mathematical analysis of heart rhythm under stress. Moscow: Nauka, 1984: 226.
  • Zemaityte DJ, Varoneckas GA, Sokolov EN. Interaction between the parasympathetic and sympathetic divisions of the autonomic nervous system in cardiac rhythm regulation. Hum Physiol. 1985; 11(3): 208-15. https://pubmed.ncbi.nlm.nih.gov/4093149/
  • Kendall M., Stewart A. Statistical inference and relationships. M., Nauka, Fizmatlit, 1973: 899.
  • Lehmann E. Theory of point estimation. M.: Nauka, 1991: 448.
  • Singer D.H. High heart rate variability, marker of healthy longevity. Am J Cardiol. 2010; 106(6): 910. https://doi.org/10.1016/j.amjcard.2010.06.038. PMID: 20816137.
  • McCraty R., Shaffer F. Heart Rate Variability: New Perspectives on Physiological Mechanisms, Assessment of Self-regulatory Capacity, and Health risk. Glob Adv Health Med. 2015; 4(1): 46-61. https://doi.org/10.7453/gahmj.2014.073.
  • Geisler F.C., Kubiak T., Siewert K., Weber H. Cardiac vagal tone is associated with social engagement and self-regulation. Biol Psychol. 2013; 93(2): 279-86. https://doi.org/10.1016/j.biopsycho.2013.02.013.
  • Reynard A., Gevirtz R., Berlow R., Brown M., Boutelle K. Heart rate variability as a marker of self-regulation. Appl Psychophysiol Biofeedback. 2011; 36(3): 209-215. https://doi.org/10.1007/s10484-011-9162-1.
  • Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Eur Heart J. 1996; 17(3): 354-381.
  • Singer D.H., Martin G.J., Magid N., Weiss J.S., et al. Low heart rate variability and sudden cardiac death. J Electrocardiol. 1988; 21(1): 46-55. https://doi.org/10.1016/0022-0736(88)90055-6.
  • Thayer J.F., Hansen A.L., Saus-Rose E., Johnsen B.H. Heart rate variability, prefrontal neural function, and cognitive performance: the neurovisceral integration perspective on self-regulation, adaptation, and health. Ann Behav Med. 2009; 37(2): 141-53. https://doi.org/10.1007/s12160-009-9101-z
  • Paltsev A.I. Chronic opisthorchiasis from the position of system approach. Clinic, diagnostics, pathomorphosis, treatment. Diseases of the digestive organs. Russ. med. zhurn. 2005; 2: 96-100.
  • Boytsov S.A. Influence of modern lifestyle on heart health. The realities of hypersympathicotonia. Efficient Pharmacotherapy. 2020; 16(5): 56-63.
  • Palatini P. Heart rate and the cardiometabolic risk. Curr. Hypertens. Rep. 2013; 15(3): 253-259. https://doi.org/10.1007/s11906-013-0342-7
  • Heusch G. Heart rate and heart failure. Not a simple relationship. Circ. J. 2011; 75(2): 229-236. https://doi.org/10.1253/circj.CJ-10-0925
    • Том 32 № 4 (2023): Бюллетень медицинской науки

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    2023-12-22

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    Plotnikova E. Y., Karbysheva N. V., Nikonorova M. A., Beskhlebova O. V., Ivanova M. E., Osipova I. V., Sinkov M. A., Kiushkina I. N. VEGETATIVE DYSFUNCTION IN CHRONIC OPISTHORCHIASIS: УДК 616.995.122:616.839 // Bulletin of Medical Science, 2023. Vol. 32, № 4. P. 94–104 DOI: 10.31684/25418475-2023-4-94. URL: https://newbmn.asmu.ru/bmn/article/view/639.

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    Vol. 32 No. 4 (2023): Bulletin of Medical Science

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    ORIGINAL PAPERS

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