IMPACT OF MICROFLORA ON PATHOMORPHOLOGICAL REORGANIZATION OF VAGINAL AND BLADDER MUCOUS MEMBRANES IN CHRONIC CYSTOPATHY

UDC 616.62-002:579.61

Abstract

Introduction. Tumor diseases of the bladder are a heterogeneous pathology with a pronounced clinical picture and the presence of infectious and viral agents. The aim is to study the urogenital microbiome and structural changes in the mucous membranes of the vagina and bladder in chronic cystopathy. Materials and methods. A clinical, endoscopic and pathomorphological study was conducted in 112 women with recurrent cystitis (87 of them with leukoplakia). Cultural and microscopic studies of biopsy samples from Pavlikov triangle and Lieto triangle were carried out; for leukoplakia, the material was also taken from the area of visually healthy tissue. Results. Pathogenic and opportunistic infections were detected in the vagina and urine; the highest activity and virulence were microorganisms inherent in the intestinal tract, most often in mixed forms. Cytomorphological analysis of pathological processes in conjugated tissues of the Lieto triangle of the bladder and Pavlikov triangle of the vagina suggests that it is possible that vagina infection from the vagina penetrates the bladder through the microcirculatory circulatory and lymphatic systems, intersynaptic fissures and interstitial nests, leading to changes characteristic of chronic cystitis, up to gross morphological forms, leukoplakia, with signs of hyperplasia and metaplasia, which refers to cancer risk markers. Conclusion. The indicated complex of clinical, endoscopic, and pathomorphological changes is identified as "chronic cystovaginitis". Prevention of urogenital zone oncological diseases is associated with the prevention of the early initiation of neoplastic processes and hence with timely diagnosis and treatment of inflammatory diseases.