LETHALITY OF ACUTE LIMB ISCHEMIA PATIENTS AND PROGNOSTIC FACTORS FOR FATAL OUTCOMES

UDC 616-005.4-717.718:613.6.02:314.42

Authors

  • Nikolay G. Khorev Altai State Medical University, Barnaul; Clinical Hospital "RZD-Medicine of Barnaul" Email: xorev-ng@mail.ru
  • Artem A. Chichvarov Altai State Medical University, Barnaul; Clinical Hospital "RZD-Medicine of Barnaul" Email: orig.xi@gmail.com
  • Sergey V. Sapelkin Vishnevsky National Medical Research Center for Surgery, Moscow Email: xorev-ng@mail.ru
  • Alexander V. Beller Altai State Medical University, Barnaul; Clinical Hospital "RZD-Medicine of Barnaul" Email: beller-alexandr@mail.ru

DOI:

https://doi.org/10.31684/25418475-2023-2-5

Keywords:

acute limb ischemia, lethality, neutrophil-lymphocyte ratio

Abstract

Materials and methods. Retrospective analysis of 1,933 inpatient treatment of patients with acute limb ischemia for 12 years (2009-2021). 63 cases of treatment ended in death. An analysis of clinical and laboratory factors influenced the lethal outcome was performed. Results and conclusions. Hospital mortality in patients with acute limb ischemia is 4.5%. The thrombotic nature of ALI often leads to death. Patients with ischemia in the basin of the lower extremities die 14.6 times more often than in the upper extremity. The leading cause of death in the structure of death is gangrene of the limbs and intestines with the development of multiple organ failure. The ratio of neutrophils to lymphocytes may be a laboratory predictor of death.

 

Downloads

Download data is not yet available.

Author information

Nikolay G. Khorev,
Altai State Medical University, Barnaul; Clinical Hospital "RZD-Medicine of Barnaul"

Dr. Sci. (Med.), Professor, Head of Department of Cardiology and Cardiovascular Surgery with the Course of Advanced Training of Altai State Medical University, Barnaul.
656038, Barnaul, Lenina Ave. 40. E-mail: xorev-ng@mail.ru Tel.: (3852) 201256.

Artem A. Chichvarov,
Altai State Medical University, Barnaul; Clinical Hospital "RZD-Medicine of Barnaul"

Postgraduate student of the Department of Cardiology and Cardiovascular Surgery with the Course of Advanced Training of Altai State Medical University, Barnaul; Resident of the Department of Vascular Surgery, Barnaul Clinical Hospital "RZD-Medicine", Barnaul.
656038, Barnaul, Molodezhnaya Str., 20, h2. E-mail: orig.xi@gmail.com Tel.: (3852) 20-12-58.

Sergey V. Sapelkin,
Vishnevsky National Medical Research Center for Surgery, Moscow

Dr. Sci. (Med.), Leading researcher, Scientific Secretary of the dissertation Council of Vishnevsky National Medical Research Center for Surgery, Moscow. 117997, Moscow, Bolshaya Serpukhovskaya Str., 27.

Alexander V. Beller,
Altai State Medical University, Barnaul; Clinical Hospital "RZD-Medicine of Barnaul"

Cand. Sci. (Med.), Head of the Department of Vascular Surgery, Barnaul Clinical Hospital "RZD-Medicine", Barnaul. 656038, Barnaul, Molodezhnaya Str., 20, h2. E-mail: beller-alexandr@mail.ru Tel.: (3852) 201257.

References

  • Acar RD, Sahin M, Kirma C. One of the most urgent vascular circumstances: Acute limb ischemia. SAGE Open Med. 2013 Dec 11; 1: 2050312113516110. https://doi.org/10.1177/2050312113516110.
  • Creager MA, Kaufman JA, Conte MS. Clinical practice. Acute limb ischemia. N Engl J Med. 2012 Jun 7; 366(23): 2198-206. https://doi.org/10.1056/NEJMcp1006054.
  • Khorev N.G., Sapelkin S.V., Beller A.V., Chichvarov A.A. Structural changes in patients with acute arterial limb ischemia. Angiology and Vascular Surgery. Academician A.V. Pokrovsky Journal. 2022; 28 (2): 45-49. (In Russ.) https://doi.org/10.33029/1027-6661-2022-28-2-45-49
  • Grip O, Wanhainen A, Michaëlsson K, Lindhagen L, Björck M. Open or endovascular revascularization in the treatment of acute lower limb ischaemia. Br J Surg. 2018 Nov; 105(12): 1598-1606. https://doi.org/10.1002/bjs.10954. Epub 2018 Jul 25.
  • Enezate TH, Omran J, Mahmud E, Patel M, Abu-Fadel MS, White CJ, Al-Dadah AS. Endovascular versus surgical treatment for acute limb ischemia: a systematic review and meta-analysis of clinical trials. Cardiovasc Diagn Ther. 2017 Jun; 7(3): 264-271. https://doi.org/10.21037/cdt.2017.03.03.
  • Baril DT, Ghosh K, Rosen AB. Trends in the incidence, treatment, and outcomes of acute lower extremity ischemia in the United States Medicare population. J Vasc Surg. 2014 Sep; 60(3): 669-77.e2. https://doi.org/10.1016/j.jvs.2014.03.244.
  • Björck M., Earnshaw J.J., Acosta S. et al. Editor’s Choice - European Society for Vascular Surgery (ESVS) 2020 Clinical Practice Guidelines on the Management of Acute Limb Ischaemia. Eur J Vasc Endovasc Surg. 2020; 59: 173e218 https://doi.org/10.1016/j.ejvs.2016.06.005.
  • Zatevakhin I.I., Tsitsiashvili M.Sh., Zolkin V.N. Acute arterial obstruction. Clinical classification and treatment tactics. Angiology and Vascular Surgery. 2002; 8(2): 74-77. (In Russ.)
  • Kremers B., Wübbeke L., Mees B. et. al. Plasma Biomarkers to Predict Cardiovascular Outcome in Patients With Peripheral Artery Disease: A Systematic Review and Meta-Analysis. Arterioscler Thromb Vasc Biol. 2020 Sep; 40(9): 2018-2032. https://doi.org/10.1161/atvbaha.120.314774l
  • European Society for Vascular Surgery (ESVS) 2020 Clinical Practice Guidelines on the Management of Acute Limb Ischaemia. Eur J Vasc Endovasc Surg. 2020; 59: 173e218. https://doi.org/10.1016/j.ejvs.2019.09.006.
  • Frank M Davis , Jeremy Albright , Katherine A Gallagher, Hitinder S Gurm, Gerald C Koenig , Theodore Schreiber , P Michael Grossman , Peter K Henke. Early Outcomes following Endovascular, Open Surgical, and Hybrid Revascularization for Lower Extremity Acute Limb Ischemia. Ann Vasc Surg. 2018 Aug; 51: 106-112. https://doi.org/10.1016/j.avsg.2017.12.025.
  • Melnikov M.V., Apresyan A.Y., Sotnikov A.V., Kozhevnikov D.S., Papava G.D. Emergency care of patients with aortic embolism and limb arteries in St. Petersburg: analysis of 3498 observations for 50 years. Bulletin of Surgery named after I.I. Grekov. 2021; 180(4): 28-34. (In Russ.) https://doi.org/10.24884/0042-4625-2021-180-4-28-34.
  • Elizabeth A Genovese, Rabih A Chaer, Ashraf G Taha, Luke K Marone, Efthymios Avgerinos, Michel S Makaroun, Donald T Baril. Risk Factors for Long-Term Mortality and Amputation after Open and Endovascular Treatment of Acute Limb Ischemia. Ann Vasc Surg. 2016 Jan; 30: 82-92. https://doi.org/10.1016/j.avsg.2015.10.004. Epub 2015 Nov 10.
  • Tasoglu I, Cicek OF, Lafci G et al. Usefulness of neutrophil/lymphocyte ratio as a predictor of amputation after embolectomy for acute limb ischemia. Ann Vasc Surg. 2014; 28: 606e13. https://doi.org/10.1016/j.avsg.2012.12.009
  • Taurino M, Aloisi F, Del Porto F, Nespola M, Dezi T, Pranteda C, Rizzo L, Sirignano P. Neutrophil-to-Lymphocyte Ratio Could Predict Outcome in Patients Presenting with Acute Limb Ischemia. J Clin Med. 2021 Sep 24; 10(19): 4343. https://doi.org/10.3390/jcm10194343.
  • Published

    2023-06-26

    How to Cite

    Khorev N. G., Chichvarov A. A., Sapelkin S. V., Beller A. V. LETHALITY OF ACUTE LIMB ISCHEMIA PATIENTS AND PROGNOSTIC FACTORS FOR FATAL OUTCOMES: UDC 616-005.4-717.718:613.6.02:314.42 // Bulletin of Medical Science, 2023. Vol. 30, № 2. P. 5–10 DOI: 10.31684/25418475-2023-2-5. URL: https://newbmn.asmu.ru/bmn/article/view/564.

    Most read articles by the same author(s)