NLR IN URINE: PROGNOSTIC MARKER FOR RECURRENT INFLAMMATORY URINARY TRACT CONDITIONS

УДК 616.61-002: 616.155.34:616.155.32

Authors

  • Vadim B. Berdichevsky Tyumen State Medical University, Tyumen, Russia Email: urotgmu@mail.ru
  • Elena I. Gutrova Tyumen State Medical University, Tyumen, Russia Email: urotgmu@mail.ru
  • Ekaterina V. Sapozhenkova Tyumen State Medical University, Tyumen, Russia Email: ekaterina_chibulaeva@mail.ru
  • Irina V. Pavlova Medical and Sanitary Unit "Neftyanik", Tyumen, Russia Email: iraena@mail.ru
  • Artem R. Gonyaev Clinical Hospital "Mother and Child", Tyumen, Russia Email: a.gonyaev25@yandex.ru
  • Alexei L. Boldyrev Regional Clinical Hospital No. 2, Tyumen, Russia Email: boldyrev.a.l@yandex.ru
  • Oksana V. Krasnousova Regional Clinical Hospital No. 1, Tyumen, Russia Email: krasnousova.oksana@mail.ru
  • Farkhod R. Rasulov Tyumen State Medical University, Tyumen, Russia Email: urotgmu@mail.ru

DOI:

https://doi.org/10.31684/25418475-2024-1-14

Keywords:

neutrophils, lymphocytes, urinary sediment, inflammation urological diseases

Abstract

Аim. The study aims to evaluate the clinical significance of the indicator of nonspecific and specific protection (NLR) in urine as an accessible and objective marker of the type, cause, and possible outcome of recurrent inflammatory diseases of the urinary tract. Materials and Methods. The study included patients with recurrent urinary tract inflammation of various origins. A comparative study of routine laboratory indicators of the ratio of neutrophils and lymphocytes, immune markers of inflammation in urine, and the results of immunohistochemical studies of biopsies of the bladder mucosa was performed. Results. The index of the ratio of cells of nonspecific and specific protection in urine significantly correlates with indicators of phenotyping of T-lymphocytes, the concentration of interleukins in urine, and the composition of cells of the mucous membrane of the bladder with the expression of antigens.  Conclusion. The index of the ratio of cells of nonspecific and specific protection (NLR) in urine can be recommended as an additional prognostic marker not only of the type and cause but also of the possible outcome of recurrent inflammatory urological diseases.

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Author information

Vadim B. Berdichevsky,
Tyumen State Medical University, Tyumen, Russia

Dr. Sci. (Med.), Professor, Department of Oncology with Urology Course, Tyumen State Medical University, Tyumen.
E-mail: urotgmu@mail.ru.

Elena I. Gutrova,
Tyumen State Medical University, Tyumen, Russia

Postgraduate student, Department of Oncology with Urology Course, Tyumen State Medical University, Tyumen.
E-mail: urotgmu@mail.ru.

Ekaterina V. Sapozhenkova,
Tyumen State Medical University, Tyumen, Russia

Cand. Sci. (Med.), Associate Professor, Department of Normal Physiology, Tyumen State Medical University, Tyumen.
E-mail: ekaterina_chibulaeva@mail.ru.

Irina V. Pavlova,
Medical and Sanitary Unit "Neftyanik", Tyumen, Russia

Urologist, Urology Department, Medical and Sanitary Unit "Neftyanik", Tyumen, Russia. E-mail: iraena@mail.ru.

Artem R. Gonyaev,
Clinical Hospital "Mother and Child", Tyumen, Russia

Urologist, Clinical Hospital "Mother and Child", Tyumen.
E-mail: a.gonyaev25@yandex.ru

Alexei L. Boldyrev,
Regional Clinical Hospital No. 2, Tyumen, Russia

Urologist, Regional Clinical Hospital No. 2, Tyumen.
E-mail: boldyrev.a.l@yandex.ru

Oksana V. Krasnousova,
Regional Clinical Hospital No. 1, Tyumen, Russia

Laboratory Technician, Immunologist, Regional Clinical Hospital No. 1, Tyumen.
E-mail: krasnousova.oksana@mail.ru

Farkhod R. Rasulov,
Tyumen State Medical University, Tyumen, Russia

Postgraduate student of Oncology Department with Urology Course, Tyumen State Medical University, Tyumen, Russia. E-mail: urotgmu@mail.ru

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    Published

    2024-03-25

    How to Cite

    Berdichevsky V. B., Gutrova E. I., Sapozhenkova E. V., Pavlova I. V., Gonyaev A. R., Boldyrev A. L., Krasnousova O. V., Rasulov F. R. NLR IN URINE: PROGNOSTIC MARKER FOR RECURRENT INFLAMMATORY URINARY TRACT CONDITIONS: УДК 616.61-002: 616.155.34:616.155.32 // Bulletin of Medical Science, 2024. Vol. 33, № 1. P. 14–21 DOI: 10.31684/25418475-2024-1-14. URL: https://newbmn.asmu.ru/bmn/article/view/658.

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    Vol. 33 No. 1 (2024): Bulletin of Medical Science

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    ORIGINAL PAPERS

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