NEUROPROTECTIVE EFFECT OF THEAFLAVINE IN EXPERIMENTAL CHRONIC CEREBROVASCULAR ACCIDENT

UDC 615.214.3:616-092.9:616.831-005:616.133

Authors

  • Dmitry I. Pozdnyakov Pyatigorsk Medical and Pharmaceutical Institute – branch of the Volgograd State Medical University, Pyatigorsk https://orcid.org/0000-0002-5595-8182 Email: Pozdniackow.dmitry@yandex.ru

DOI:

https://doi.org/10.31684/25418475-2023-2-72

Keywords:

neuroprotection, flavonoids, theaflavin, mitochondrial dysfunction, cerebrovascular disorders

Abstract

Introduction. Theaflavin is a polyphenol derived from black tea, known for its antioxidant properties. The high pharmacological activity of theaflavine, as well as the availability of raw materials, make this compound a promising neuroprotector agent. Materials and methods. The experiment was carried out on male Wistar rats, in which a chronic cerebrovascular accident was modeled by partial bilateral occlusion of the common carotid arteries. Tefalavin was administered orally at doses of 25, 50 and 100 mg/kg after simulation of ischemia and then once a day for 14 days. During the experiment, the following indicators were analyzed: cognitive deficit, changes in brain neurotrophic factor, succinate deigdrogenase and cytochrome c oxidase activity. Results. As a result, the use of theaflavine at a dose of 25 mg / kg was found to contribute to an increase in the activity of succinate dehydrogenase and cytochrome c oxidase of 45.7% (p <0.05) and 100.2% (p <0.05), respectively. The level of brain neurotrophic factor in rats treated with theaflavine was significantly higher dose-independent than in untreated animals. There was also a decrease in cognitive deficits in animals treated with theaflavine. Conclusion. Theaflavin in the experiment has a neuroprotective effect by restoring mitochondrial function and increasing the concentration in the neurotrophic factor of the brain, making it a promising object for further study.

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Author information

Dmitry I. Pozdnyakov,
Pyatigorsk Medical and Pharmaceutical Institute – branch of the Volgograd State Medical University, Pyatigorsk

Cand. Sci. (Pharm.), Associate Professor, Head of the Department of Pharmacology with a Course in Clinical pharmacology. Pyatigorsk Medical and Pharmaceutical Institute - branch of the Volgograd State Medical University.
357532, Stavropol Region, Pyatigorsk, Kalinin Ave., 11.
Tel.:8-918-756-08-89.
E-mail: Pozdniackow.dmitry@yandex.ru.
https://orcid.org/0000-0002-5595-8182.

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    2023-06-26

    How to Cite

    Pozdnyakov D. I. NEUROPROTECTIVE EFFECT OF THEAFLAVINE IN EXPERIMENTAL CHRONIC CEREBROVASCULAR ACCIDENT: UDC 615.214.3:616-092.9:616.831-005:616.133 // Bulletin of Medical Science, 2023. Vol. 30, № 2. P. 72–78 DOI: 10.31684/25418475-2023-2-72. URL: https://newbmn.asmu.ru/bmn/article/view/573.

    Issue

    Vol. 30 No. 2 (2023): Bulletin of Medical Science

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    ORIGINAL PAPERS

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