THE OUTCOMES OF RADICAL SURGICAL TREATMENT OF HEPATOCELLULAR CANCER AND THE ROLE OF ENDOTHELIAL DYSFUNCTION

UDC 616.36-006-089.84 Surgery

Authors

  • S. T. Olzhaev Almaty Regional Oncological Dispenser, Almaty, Republic of Kazakhstan Email: s.olzhayev20@gmail.com
  • A. F. Lazarev Altai Regional Oncological Dispenser, Barnaul, Russian Federation; Altai State Medical University, Barnaul, Russian Federation Email: lazarev@akzs.ru
  • Ya. N. Shoikhet Altai State Medical University, Barnaul, Russia Email: starok100@mail.ru

DOI:

https://doi.org/10.31684/25418475-2021-4-26

Keywords:

endothelial dysfunction, hepatocellular cancer

Abstract

The current work evaluates the characteristics of changes in the functional state of the endothelium depending on the immediate and delayed results of radical surgical treatment of patients with hepatocellular cancer.
Materials and methods: The study is based on data on 39 patients diagnosed with hepar cancer - hepatocellular carcinoma. Results: There were sharp differences in endothelial status indicators compared with the control group, consisting of an increase in the number of circulating endotheliocytes, the content of PV and a decrease in ESVD.
A significantly higher incidence of postoperative complications was revealed in the presence of a pronounced degree of endothelial dysfunction.
Conclusion: The presence of endothelial dysfunction and its high degree correspond to a greater risk of complications in the immediate postoperative period, as well as relapses and metastases in patients undergoing radical surgery for hepatocellular cancer.

Downloads

Download data is not yet available.

Author information

S. T. Olzhaev,
Almaty Regional Oncological Dispenser, Almaty, Republic of Kazakhstan

Candidate of Medical Sciences, Chief Physician of the Almaty Regional Oncological Dispensary, Almaty, Republic of Kazakhstan
Tel: 8 (727) 231-05-66
E-mail: arod_priem@mail.ru, s.olzhayev20@gmail.com

A. F. Lazarev,
Altai Regional Oncological Dispenser, Barnaul, Russian Federation; Altai State Medical University, Barnaul, Russian Federation

Doctor of Medical Sciences, Professor, Head of the Department of Oncology, Radiation Therapy and Radiation Diagnostics with a Course of Advanced Training of Altai State Medical University; Director of Altai Branch of N.N. Blokhin Russian Cancer Research Center, Barnaul
656038, Altai Krai, Barnaul, 40 Lenin Ave.
Tel.: +7 (3852) 507-344
E-mail: lazarev@akzs.ru

Ya. N. Shoikhet,
Altai State Medical University, Barnaul, Russia

Doctor of Medical Sciences, Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Department of Faculty Surgery named after Professor I.I. Neumark with a Course of Advanced Training, Altai State Medical University, Ministry of Healthcare of the Russian Federation, Barnaul.
656038, Altai Krai, Barnaul, Lenin Ave. 40.
Tel.: +7 (3852) 566-959
E-mail: starok100@mail.ru

References

  • Drake TM, Søreide K. Cancer epigenetics in solid organ tumours: A primer for surgical oncologists. Eur J Surg Oncol. 2019; 45(5): 736-746. doi: 10.1016/j.ejso.2019.02.005.
  • Sugarbaker PH. Peritoneal Metastases from Gastrointestinal Cancer. Curr Oncol Rep. 2018; 20(8): 62-68. doi: 10.1007/s11912-018-0703-0.
  • Virgilio E, Balducci G, Mercantini P, Giarnieri E, Giovagnoli MR, Montagnini M, Proietti A, D'Urso R, Cavallini M. Preoperative gastric lavage in gastric cancer patients undergoing surgical, endoscopic or minimally invasive treatment: An oncological measure preventing peritoneal spillage of intragastric cancer cells and development of related metastases. Med Hypotheses. 2018; 114: 30-34. doi: 10.1016/j.mehy.2018.02.023.
  • Alieva M, van Rheenen J, Broekman MLD. Potential impact of invasive surgical procedures on primary tumor growth and metastasis. Clin Exp Metastasis. 2018; 35(4): 319-331. doi: 10.1007/s1
  • Emoto S, Ishigami H, Yamaguchi H, Ishihara S, Sunami E, Kitayama J, Watanabe T. Port-site metastasis after laparoscopic surgery for gastrointestinal cancer. Surg Today. 2017; 47(3): 280-283. doi: 10.1007/s00595-016-1346-0.
  • Behrenbruch C, Shembrey C, Paquet-Fifield S, Mølck C, Cho HJ, Michael M, Thomson BNJ, Heriot AG, Hollande F. Surgical stress response and promotion of metastasis in colorectal cancer: a complex and heterogeneous process. Clin Exp Metastasis. 2018; 35(4): 333-345. doi: 10.1007/s10585-018-9873-2.
  • Hiller JG, Perry NJ, Poulogiannis G, Riedel B, Sloan EK. Perioperative events influence cancer recurrence risk after surgery. Nat Rev Clin Oncol. 2018; 15(4): 205-218. doi: 10.1038/nrclinonc.2017.194.
  • Hladovec J. Circulating endothelial cells as a sign of vessel wall lesions. Physiol Bohemoslov.1978; 27(2): 140-144.
  • Momot AP, Tsyvkina LP, Taranenko IA Modern methods of recognition of the state of thrombotic readiness: a monograph. Barnaul: Alt. Univ. Publishing House. 2011; 138 p.
  • Celermajer D, Sorensen KE, Gooch VM et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 1992; 340: 1111-1115.
  • Evans CE, Palazon A, Sim J, Tyrakis PA, Prodger A, Lu X, Chan S, Bendahl PO, Belting M, Von Euler L, Rundqvist H, Johnson RS, Branco C. Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesis. Biol Open. 2017; 6(5): 688-697. doi: 10.1242/bio.024653.
    • НастройкиТом 24 № 4 (2021): Бюллетень медицинской науки

    Downloads

    Published

    2021-12-29

    How to Cite

    Olzhaev S. T., Lazarev A. F., Shoikhet Y. N. THE OUTCOMES OF RADICAL SURGICAL TREATMENT OF HEPATOCELLULAR CANCER AND THE ROLE OF ENDOTHELIAL DYSFUNCTION : UDC 616.36-006-089.84 Surgery // Bulletin of Medical Science, 2021. Vol. 24, № 4. P. 26–32 DOI: 10.31684/25418475-2021-4-26. URL: https://newbmn.asmu.ru/bmn/article/view/270.

    Issue

    Vol. 24 No. 4 (2021): Bulletin of Medical Science

    Section

    ORIGINAL PAPERS

    License

    Creative Commons License

    This work is licensed under a Creative Commons Attribution 4.0 International License.