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АЛТАЙСКИЙ ГОСУДАРСТВЕННЫЙ МЕДИЦИНСКИЙ УНИВЕРСИТЕТ
Бюллетень медицинской науки

ДИАБЕТИЧЕСКАЯ КАРДИОМИОПАТИЯ: СОВРЕМЕННОЕ СОСТОЯНИЕ ПРОБЛЕМЫ

ДИАБЕТИЧЕСКАЯ КАРДИОМИОПАТИЯ: СОВРЕМЕННОЕ СОСТОЯНИЕ ПРОБЛЕМЫ

УДК 616.379-008.64-073.756.8:615.272
DOI: 10.31684/25418475-2025-2-92

Шаронин Александр Дмитриевич
Федеральный исследовательский центр фундаментальной и трансляционной медицины (ФИЦ ФТМ), г. Новосибирск

Ложкина Наталья Геннадьевна
Федеральный исследовательский центр фундаментальной и трансляционной медицины, г. Новосибирск
Новосибирский национальный исследовательский государственный университет, г. Новосибирск
Ключевые слова: диабетическая дисфункция миокарда, диабетическая кардиомиопатия, сахарный диабет, патогенез, диагностика, лечение, эхокардиография, магнитно-резонансная томография, биомаркеры, антиоксиданты, ренин-ангиотензиновая система
Аннотация:

В данной обзорной статье представлен комплексный анализ современных исследований, посвященных диабетической кардиомиопатии (ДКМ) или, как советует Европейское общество кардиологов, диабетической дисфункции миокарда (ДДМ), а также связанной с ней сердечной недостаточности. Статья начинается с обзора патофизиологических механизмов, лежащих в основе ДКМ, включая влияние гипергликемии, окислительного стресса, ишемии и ремоделирования сердца. Далее рассматриваются современные методы диагностики, такие как эхокардиография, магнитно-резонансная томография и биомаркеры, подчеркивая важность раннего выявления и мониторинга. В заключительной части статьи обсуждаются стратегии лечения ДКМ, включая модификацию образа жизни, контроль гликемии, применение современных сахароснижающих препаратов и ингибиторов ренин-ангиотензиновой системы. Также в статье уделяется внимание новым подходам, в частности использованию миРНК и клеточных терапий, а также перспективам исследований в области персонализированной медицины. Анализировались сведения по теме из публикаций на основе баз данных PubMed, Google Scholar и eLIBRARY, глубина охвата 35 лет.

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Информация об авторах

Шаронин Александр Дмитриевич
аспирант, Федеральный исследовательский центр фундаментальной и трансляционной медицины (ФИЦ ФТМ), г. Новосибирск.
E-mail: lozhkina.n@mail.ru
SPIN-код: 4834-3520
https://orcid.org/0000-0003-0713-0337

Ложкина Наталья Геннадьевна
д. м. н., профессор, руководитель группы «Клиническая и экспериментальная кардиология», ФИЦ ФТМ; профессор кафедры иммунологии, Новосибирский национальный исследовательский государственный университет; кардиолог, куратор отделения для лечения больных с острым коронарным синдромом РСЦ № 1 ГКБ № 1, г. Новосибирск.
E-mail: lozhkina.n@mail.ru
SPIN-код: 5320-7554
https://orcid.org/0000-0002-4832-3197